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Postdoctoral Research Associate - Fish Immunology

Apply now Job no: 500065
Position type: Staff Full Time
Benefit Status: Benefited-Non-Union
Campus: UMass Lowell
Department: Biological Sciences
Salary: Salary commensurate with experience
Applications Open:
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General Summary of Position:

The Steinel lab at the University of Massachusetts Lowell is seeking a qualified candidate for a Postdoctoral Research Associate position starting in the Fall of 2019. The Steinel lab current interests include fish lymphocyte biology and host-pathogen co-evolution. The postdoctoral research associate will have the opportunity to train in the burgeoning field of eco-immunology and gain experience working in non-mouse animal models.

The postdoctoral research associate will study the adaptive humoral immune response in the fish, threespine stickleback. Though fish B cells proliferate and generate high affinity antibodies in response to antigen, they do so in the absence of germinal centers. The fish B cell response is thought to occur in the melanomacrophage center (MMC), a proposed “evolutionary precursor” to the mammalian germinal center, however a rigorous testing of this hypothesis has not yet been performed. The postdoctoral fellow will lead studies to characterize the MMC and B cell response in fish and determine the MMC’s evolutionary relationship to the mammalian GC response. This work will particularly focus on the MMC’s response to helminth infection.

The project will involve, but is not limited to, the development and application of imaging techniques to identify and track fish lymphocytes (RNA-FISH, immunofluorescence, confocal microscopy) as well as gene expression analysis (bulk RNAseq, single cell RNAseq) of fish lymphoid tissues. While the majority of work will be conducted in the lab, the postdoctoral research associate will have the option to conduct field research at domestic and international sites. These field studies will investigate the eco-immunological functions of MMCs in wild stickleback populations. 

Minimum Qualifications (Required):

  • Candidates must have a PhD or equivalent by the time of the appointment
  • Postdoctoral experience: 0-3 years
  • A record of peer-reviewed publications
  • Experience with collaborative interdisciplinary research
  • Knowledge of current immunologic principles and techniques
  • Knowledge of modern research methods, data collection, and analyses

  • Ideal candidates will have strong training in immunology, with preference going to candidates with experience in B cell and/or germinal center biology.

Additional Considerations:

  • Hands-on experience in one or more of the following is desired: fish model systems, B cell biology, germinal centers, cellular and molecular immunology, cell culture, gene expression analysis, RNAseq, single cell RNAseq, histology, RNA-FISH, confocal and epifluorescence microscopy, multi-parameter flow cytometry, and/or R programming language.

Special Instructions for Applicants:

Only current UML Employees within the Grants & Contracts (MTA/GRACE) bargaining unit will be considered during the first 10 business days of the posting.  All other candidates will be considered after that period.

Initial review of applications will begin immediately and continue until the position is filled. However, the position may close when an adequate number of qualified applications are received.   

This position is contingent upon funding. The initial appointment will be for one year with a possibility of renewal contingent upon funding and successful performance.

Please include a resume and cover letter with your application. Names and contact information of three references will be required during the application process. 

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